Structural Classification of Protein-Protein Interfaces

SCOPPI is a database of all domain-domain interactions and their interfaces derived from PDB structure files and SCOP domain definitions. Interfaces are classified according to the geometry of the domain associations and are annotated with various interaction characteristics. Screenshots of all interfaces are available.

new  SCOPPI has been updated to SCOP version 1.75. Previous versions can be found here: 1.67 1.69

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Examples of usage
Just click on one of the following examples:

Enter a SCOP family ID: "b.47.1.1"
Enter a SCOP superfamily ID: "c.37.1"
Enter a PDB id: "1kim"
Enter a list of space separated PDB ids: "1alk 1kim 1bob"
Enter a keyword: "gtpase"
Take a quick look at interface screenshots of PDB 1ky9
Overall statistics of most versatile domain-domain interactions

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ABAC Database
An Exhaustive Screen for Equivalent Binding Sites of Domains Reveals Convergently Evolved Interaction Motifs.

Structural Characterization Of Water, Ligands and Proteins

Winter C, Henschel A, Kim WK, Schroeder M.
SCOPPI: a structural classification of protein-protein interfaces.
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D310-4.

Kim WK, Ison JC
Survey of the geometric association of domain-domain interfaces.
Proteins. 2005 Dec 1;61(4):1075-88.

Kim WK, Henschel A, Winter C, Schroeder M
The Many Faces of Protein-Protein Interactions: A Compendium of Interface Geometry.
PLoS Computational Biology. 2006 Sep 29;2(9):e124.


SCOPPI is developed by Gihan Dawelbait, Andreas Henschel, Wan Kyu Kim, Samatha Kottha, Christof Winter and Michael Schroeder.

Comments, questions or problems? Please contact

Funding by EFRE Project CODI (4212/04-07) and EU Project REWERSE (IST-2004- 506779) is kindly acknowledged.

Bioinformatics Group
Dresden University of Technology

Last update: June 3, 2010