 Movie generated with PyMOL |
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A: d.40.1.1 (red/blue) 
B: b.47.1.2 (yellow) 
C: c.41.1.1 (green) 
Geometric Parameters
| RMSD A1-A2 | 1.51 |
| Shared interface atoms | 411 (95.6%) |
| Angle between green and yellow interface: | 8.84 |
| Angle between green and yellow domain: | 7.02 |
| Distance between center of mass of green and yellow interface (in Angstrom): | 2.82 |
| Distance between center of mass of green and yellow domain (in Angstrom) | 3.33 |
Sequence Alignment of domain d.40.1.1
-ksfpevvgktvdqareyftlhypqydvyflpeGSPVTLDLRYnRvRvFynpgtnvvnhVpHvg ktewpelvgksveeakkvilqdkpaaqiIVLPvGTIVTMEYRidrvRlfvdk-ldniaQvpRvg ____ #:.##::.#_ _ # _ __ . | |
Aligned interface residues . : # | 11 (68%) |
Aligned, similar interface residues (with positive BLOSUM value) : # | 8 (50%) |
| Raw BLOSUM-Score for the latter residues | 30 |
| Meaning | |
|---|---|
Capital letters |
Residue interacts with domain A |
# |
Identical interacting residues |
: |
Residues are similar and interact |
. |
Residues are not similar and interact |
_ |
Only one residue interacts |
Sequences of domain b.47.1.2 and c.41.1.1
cgvpaiqpvlsglivngeeavpgswpwqvslqdktgFHFCggslinenwvvtaaHCGvttsdvvvagefdqgsssekiqk lkiakvfknskynsltInnditllklstaasfsqtvsavclpsasddfaagttcvttgwgLtrYanTpdrlqqaslplls ntnckkyWgtKikdamicagasgvsSCMGDSggplvckkngawtlvgiVSWGSStCststpgvyarvtalvnwvqqtlaa n aqsvpygvsqikapalhsqgytgsnvkvaviDsgidsshpdlkvaggasmvpsetnpfqdnNSHgthvagtvaalnnsig vlgvapsaslyavkvLgaDGSGQYswIingiewaiannmdvinmSLGGPsgsaaLkaavdkavasgvvvvaAaGNEGtsg ssstvgYpgkypsviavgavdssnqrasFssvgpeldvmapgvsiqstlpgnkygaYNGTSMasphvagaaalilskhpn wtntqvrsslentttklgdsfyygkglinvqaaaqhhhhhh |
Similarities between domain b.47.1.2 and c.41.1.1
| Residue Pair | Atom Matches | BLOSUM | Score | Avg.-Distance |
|---|---|---|---|---|
| His57-His64 | 
|
8 | 12.39 | 1.54 |
| Gly193-Gly219 |
|
6 | 7.95 | 1.05 |
| Ser195-Ser221 |
|
4 | 6.28 | 1.63 |
| Gly216-Gly127 | |
6 | 6.01 | 2.98 |
| Ser214-Ser125 |
|
4 | 4.08 | 2.88 |
| Phe41-Asn218 |
|
-3 | 3.72 | 1.41 |
| Phe41-Tyr217 | |
3 | 3.37 | 1.88 |
| Trp172-Ile107 |
|
-3 | 2.60 | 1.44 |
| Trp215-Leu96 |
|
-2 | 2.44 | 1.17 |
| Asp194-Ser221 |
|
0 | 2.19 | 1.36 |
| Ser217-Gly127 |
|
0 | 2.23 | 1.32 |
| Ser190-Ala152 |
|
1 | 2.02 | 2.24 |
| Ile99-Leu96 | |
2 | 2.02 | 2.95 |
| Ser214-Asp32 |
|
0 | 2.03 | 0.97 |
| Leu143-Gly154 |
|
-4 | 1.80 | 1.65 |
| Val213-Ser125 |
|
-2 | 1.69 | 1.31 |
| Asp194-Thr220 |
|
-1 | 1.67 | 1.33 |
| Cys220-Tyr167 |
|
-2 | 1.58 | 1.42 |
| Cys58-Tyr217 |
|
-2 | 1.32 | 1.68 |
| Met192-Asn155 |
|
-2 | 1.38 | 1.62 |
| Cys42-Met222 |
|
-1 | 1.04 | 1.43 |
| Trp215-Leu126 | |
-2 | 0.72 | 0.84 |
| His57-Ser63 | |
-1 | 0.79 | 0.62 |
| Gly193-Thr220 |
|
-2 | 0.89 | 1.67 |
| Ser195-His64 | |
-1 | 0.60 | 1.19 |
| Trp172-Gln103 | |
-2 | 0.61 | 1.18 |
| Leu143-Phe189 | |
0 | 0.54 | 1.38 |
| Thr151-Phe189 |
|
-2 | 0.42 | 2.37 |
| Cys220-Gly128 | |
-3 | 0.50 | 1.51 |
| Trp215-Asp32 | |
-4 | 0.59 | 1.24 |
| Tyr146-Glu156 | |
-2 | 0.57 | 1.29 |
| Cys191-Thr220 | |
-1 | 0.35 | 1.94 |
| Cys58-Met222 | |
-1 | 0.35 | 1.94 |
| Ser195-Met222 | |
-1 | 0.41 | 1.76 |
| Cys42-Asn218 | |
-3 | 0.31 | 2.08 |
| Cys191-Ala152 | |
0 | 0.40 | 1.80 |
| Ser218-Gly127 |
|
0 | 0.37 | 2.45 |
| Phe39-Asn218 | |
-3 | 0.38 | 1.86 |
| Ser214-His64 | |
-1 | 0.40 | 1.81 |
| Ser190-Leu126 | |
-2 | 0.29 | 2.13 |
| Met192-Thr220 |
|
-1 | 0.16 | 2.75 |
| Asp194-Ala152 | |
-2 | 0.25 | 2.24 |
| Ser218-Gly128 | |
0 | 0.01 | 2.97 |
| Cys42-Tyr217 | |
-2 | 0.08 | 2.75 |
| Cys191-Gly154 | |
-3 | 0.04 | 2.89 |
| Total Score | 79.83 | |||
| | ||||
| Symbol | Atom match between | |||
| C-alpha atoms within 3 A | |||
| C-beta atoms within 3 A | |||
| backbone atoms within 3 A | |||
| side chain atoms within 2 A | |||
|
The score for each residue pair is simply its BLOSUM score (if positive) + the sum of atom pair scores. The latter are between 0 and 1, with 0 for 3A distance or above and 1 for exact coordinate matches, linearly interpolated. | ||||
