 Movie generated with PyMOL |
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A: d.153.1.1 (red/blue) 
B: c.26.2.1 (yellow) 
C: c.61.1.1 (green) 
Geometric Parameters
| RMSD A1-A2 | 1.80 |
| Shared interface atoms | 574 (84.3%) |
| Angle between green and yellow interface: | 9.29 |
| Angle between green and yellow domain: | 29.19 |
| Distance between center of mass of green and yellow interface (in Angstrom): | 2.81 |
| Distance between center of mass of green and yellow domain (in Angstrom) | 14.81 |
Sequence Alignment of domain d.153.1.1
VLPaaFgflasa------------------r---------------------gpvFATRgshtdidtpqgerslaatlvh -----CgvfgiwgheeapqityyglHSlqHRgqegagivatdgekltahkgqgli---tEvfqngelskvkgkgaighvr . _ __ APSvapdr------avarsltgapttavlaGEiYNrdE----llsvlpagpapegdaelvlrl--------lerydlhaf YaT----gyenvqpllfrsqnngslalahNGNLVNATQlkqq-lenqgsifqtSsDtevlahlikrsghftlkdqiknsl ._: _#._.#__: _ _ RLVNgRfatvvrt-gdrvllatdHAgSVPlYtcvapgevrasTEAKAlAagfpladaRrVAGLtgvyQVPAgavmdidlg smlKGAyaflimte-temivaldpNGLRPlsigmmgdayvvasETCa----------fDVvgatYlrEvepgemliinde ___._. _._..# _ _#.._ __#___ _ :___ sgtavthRtWT--- gmkserfsmniNRS _ __ | |
Aligned interface residues . : # | 19 (42%) |
Aligned, similar interface residues (with positive BLOSUM value) : # | 8 (17%) |
| Raw BLOSUM-Score for the latter residues | 33 |
| Meaning | |
|---|---|
Capital letters |
Residue interacts with domain A |
# |
Identical interacting residues |
: |
Residues are similar and interact |
. |
Residues are not similar and interact |
_ |
Only one residue interacts |
Sequences of domain c.26.2.1 and c.61.1.1
PGlsrrilpegeavaavraaleKavaQRvTpgDtplvvlsggidssgvaacahraageldtvsmgtdtsnefrearavvd hlrtrhreitipttellaqlpyavWASEsVdpdiieyllpltalyraldgpERRiltgygadiplggmhredrlpaldtv lahdMatFDGlNeMSPVlsTLAGhWTTHpyWDREvLDllvsleaglkrrhgrdkwvlraamadalpaetvnrpklgvheg sgttssfsrllldhgvaedrvheakrqvvRelFDlTVGggrhpsevdtddvvrsvadr ICsmEyiyFSRpDSNIDGinvhsarknlgkmlaqesaveadvvtgvpdssisaaigyaeatgipyelgliknryvgRtfi qpsqalreqgvrmklsavrgvvegkrvvmvddsivrgttsrrivtmlreagatevhvkissppiahpcFYGIDTStHeel iasshsveeirqeigadtlsflsvegllkgigRkYdDsNcGQClacftgkyPTEIYqDTVlPHvK |
Similarities between domain c.26.2.1 and c.61.1.1
| Residue Pair | Atom Matches | BLOSUM | Score | Avg.-Distance |
|---|---|---|---|---|
| Glu403-Glu448 | 
|
5 | 6.95 | 1.54 |
| Trp400-Pro446 | 
|
-4 | 5.50 | 0.94 |
| Thr395-Thr388 | |
5 | 5.32 | 2.04 |
| Trp394-Thr388 |
|
-2 | 3.15 | 0.64 |
| Gln236-Thr453 |
|
-1 | 3.08 | 1.46 |
| Asp401-Glu448 |
|
2 | 3.06 | 1.41 |
| Trp394-Tyr384 |
|
2 | 2.82 | 1.77 |
| Asp401-Thr447 |
|
-1 | 2.80 | 1.60 |
| Arg343-Ser389 |
|
-1 | 2.61 | 2.02 |
| Glu317-Ile250 |
|
-3 | 2.23 | 1.89 |
| Met383-Cys236 |
|
-1 | 2.23 | 1.33 |
| Trp394-Gly385 |
|
-2 | 2.12 | 1.41 |
| Met383-Ile235 |
|
1 | 2.18 | 1.23 |
| Arg343-Pro456 |
|
-2 | 2.03 | 0.97 |
| Arg237-Phe383 |
|
-3 | 1.78 | 1.22 |
| Lys232-Tyr450 |
|
-2 | 1.59 | 1.80 |
| Trp394-Asp387 |
|
-4 | 1.49 | 1.51 |
| Arg342-Ser389 |
|
-1 | 1.43 | 1.57 |
| Val386-Glu239 |
|
-2 | 1.42 | 1.58 |
| His397-Cys437 |
|
-3 | 1.46 | 1.54 |
| Phe482-Asn249 |
|
-3 | 1.50 | 1.50 |
| Thr389-Phe243 |
|
-2 | 1.47 | 0.79 |
| Thr485-Asp247 |
|
-1 | 1.21 | 2.09 |
| Met383-Cys437 |
|
-1 | 1.25 | 1.75 |
| Val386-Phe243 |
|
-1 | 1.19 | 1.81 |
| Ser384-Glu239 |
|
0 | 1.06 | 1.94 |
| Ser384-Cys236 |
|
-1 | 1.11 | 2.17 |
| Ser316-Ile250 |
|
-2 | 0.93 | 2.07 |
| Lys232-Ile449 |
|
-3 | 0.95 | 1.58 |
| Asp242-His391 |
|
-1 | 0.96 | 1.56 |
| Trp314-Arg245 |
|
-3 | 0.75 | 2.25 |
| Val486-Asp247 |
|
-3 | 0.75 | 2.25 |
| Val319-Gly252 | |
-3 | 0.61 | 1.16 |
| Gln236-Tyr450 |
|
-1 | 0.61 | 2.09 |
| Ala315-Glu239 |
|
-1 | 0.66 | 2.34 |
| Gly379-Asp251 | |
-1 | 0.48 | 1.56 |
| Asp242-His457 | |
-1 | 0.46 | 1.61 |
| Asn381-Ile250 | |
-3 | 0.40 | 1.81 |
| Arg237-Ile449 | |
-3 | 0.49 | 1.53 |
| Val386-Ser244 |
|
-2 | 0.49 | 2.27 |
| His397-Pro446 |
|
-2 | 0.48 | 2.28 |
| Pro385-Glu239 | |
-1 | 0.38 | 1.87 |
| Arg237-Tyr384 | |
-2 | 0.47 | 1.60 |
| Val486-Ser248 | |
-2 | 0.49 | 1.53 |
| Gln236-Val454 |
|
-2 | 0.34 | 2.49 |
| Glu317-Ser248 | |
0 | 0.36 | 1.93 |
| Val486-Asn249 |
|
-3 | 0.42 | 2.37 |
| Leu390-Phe243 |
|
0 | 0.23 | 2.66 |
| Ser316-Glu239 | |
0 | 0.04 | 2.89 |
| Total Score | 75.75 | |||
| | ||||
| Symbol | Atom match between | |||
| C-alpha atoms within 3 A | |||
| C-beta atoms within 3 A | |||
| backbone atoms within 3 A | |||
| side chain atoms within 2 A | |||
|
The score for each residue pair is simply its BLOSUM score (if positive) + the sum of atom pair scores. The latter are between 0 and 1, with 0 for 3A distance or above and 1 for exact coordinate matches, linearly interpolated. | ||||
