ABAC Database

Movie generated with PyMOL

A: c.37.1.8 (red/blue)

View c.37.1.8 in Scoppi
PDB: 1wq1 (Search literature with GoPubMed)
FA: G proteins
SF: P-loop containing nucleoside triphosphate hydrolases
SP: Human (Homo sapiens)/Human (Homo sapiens)

B: a.116.1.2 (yellow)

View a.116.1.2 in Scoppi
PDB: 1wq1 (Search literature with GoPubMed)
FA: p120GAP domain-like
SF: GTPase activation domain, GAP
SP: Human (Homo sapiens)

C: c.10.1.2 (green)

View c.10.1.2 in Scoppi
PDB: 1k5d_1
FA: Rna1p (RanGAP1), N-terminal domain
SF: RNI-like
SP: Fission yeast (Schizosaccharomyces pombe)

	Center of mass, domain c.37.1.8
	Center of mass, domain a.116.1.2
	Center of mass of interface atoms, domain a.116.1.2
	Center of mass, domain c.10.1.2
	Center of mass of interface atoms, domain c.10.1.2

Geometric Parameters

RMSD A1-A2	1.24
Shared interface atoms	510 (63.6%)
Angle between green and yellow interface:	23.67
Angle between green and yellow domain:	20.61
Distance between center of mass of green and yellow interface (in Angstrom):	9.24
Distance between center of mass of green and yellow domain (in Angstrom)	10.46

Sequence Alignment of domain c.37.1.8

	Meaning
mteyklvvvgAGGvgkSaltIqliQnhfvDEYDPTIEDSY-RkqvvidgetclldildtaGQEEYsAMrdqymrtgegfl qvqfklvlvgDGGtgkttfvkrhltgefekKYVATLGVEvhplvfhtnrgpikfnvwdtAGQEKfggLRdgYyiqaqcai .## _ _ _ _:#..#:..._ _ _###:_ _:_ _ cvfainNtKsfeDihqyreqikrvkdsddvpmvlvgnKcdlaartvesrqaqdlarsyg-ipyietsakt---------- imfDvTSRVTyKNvpnw--hrdlvrvcenipivlcgnKvd--iKDRKvKaksivfhrkknlqyydisaksnynfekpflw _ _:_._ _: # ____ _ -------rqgve-----------dafytlvreirqh-------------- larkligdpnlefvampalappevvmdpalaaqyehdlevaqttalpded

Aligned interface residues . : #	21 (61%)
Aligned, similar interface residues (with positive BLOSUM value) : #	14 (41%)
Raw BLOSUM-Score for the latter residues	53


Capital letters	Residue interacts with domain A
#	Identical interacting residues
:	Residues are similar and interact
.	Residues are not similar and interact
_	Only one residue interacts

Sequences of domain a.116.1.2 and c.10.1.2

mpeeeysefkelilqkelhvvyalshvcgqdRTllasillriflhekleslllctlndreismedeATTLFRATTlaSTl mEqymKatatqfvhhalkdsilkimeskqscelspSkleknedvntnlthllnilselvekifmaseilpptlryiygcl qksvqhkwptnttmrtRvvsGfvFLRliCPaiLNprmfniisdspspiaaRtlIlvAKsvQNlaNlVefgAKEpYmegvn pfiksnkhrmimfldelgnvpelpdttehsrtdlsrdlaalheicvahsdelrtlsnergaqqhvlkkllaitellqqkq arfsiegkSLkldaittedeksvfavlleddsvkeivlsGNTigteaarwlseniaskkdleiaefsDiFTGRVKdeIPe alrlllqallkcpklhtvrlsDNAFGPTaqeplidflskhtplehlylhNNGLGPQagakiaralqelavnkkaknappl rsiicgRNRlengsmkewaktfqshrllhtvkmVQngiRpegiehllleglaycqelkvldlQDNTfThlgssalaialk swpnlrelglnDCLlsargaaavvdafskleniglqtlrlqYneieldavrtlktvidekmpdllflelngnrfseeddv vdeirevfstrgrgeldelddmEe



mpeeeysefkelilqkelhvvyalshvcgqdRTllasillriflhekleslllctlndreismedeATTLFRATTlaSTl 
mEqymKatatqfvhhalkdsilkimeskqscelspSkleknedvntnlthllnilselvekifmaseilpptlryiygcl 
qksvqhkwptnttmrtRvvsGfvFLRliCPaiLNprmfniisdspspiaaRtlIlvAKsvQNlaNlVefgAKEpYmegvn 
pfiksnkhrmimfldelgnvpelpdttehsrtdlsrdlaalheicvahsdelrtlsnergaqqhvlkkllaitellqqkq 


arfsiegkSLkldaittedeksvfavlleddsvkeivlsGNTigteaarwlseniaskkdleiaefsDiFTGRVKdeIPe 
alrlllqallkcpklhtvrlsDNAFGPTaqeplidflskhtplehlylhNNGLGPQagakiaralqelavnkkaknappl 
rsiicgRNRlengsmkewaktfqshrllhtvkmVQngiRpegiehllleglaycqelkvldlQDNTfThlgssalaialk 
swpnlrelglnDCLlsargaaavvdafskleniglqtlrlqYneieldavrtlktvidekmpdllflelngnrfseeddv 
vdeirevfstrgrgeldelddmEe

Similarities between domain a.116.1.2 and c.10.1.2

Residue Pair	BLOSUM	Score	Avg.-Distance
Lys935-Lys76	5	6.87	1.59
Phe901-Phe106	6	6.44	1.69
Arg789-Arg168	5	5.79	1.81
Asn911-Thr43	0	5.09	1.30
Phe788-Asn169	-3	4.05	1.26
Ile931-Val75	3	3.99	1.52
Thr786-Arg170	-1	3.84	1.56
Arg894-Gln137	1	3.34	1.60
Glu799-Asp103	2	3.24	1.15
Pro907-Phe71	-4	2.50	1.75
Arg903-Asn131	0	2.26	1.30
Cys906-Ile79	-1	1.92	1.56
Arg903-Asn132	0	1.66	1.34
Thr791-Arg168	-1	1.74	1.26
Leu787-Asn169	-3	1.80	1.20
Leu902-Phe106	0	1.38	1.97
Arg903-Asn104	0	1.46	1.90
Gln938-Lys76	1	1.18	2.73
Ala784-Arg170	-1	1.23	1.77
Ser795-Asn131	1	1.04	2.88
Ala934-Lys76	-1	1.11	1.89
Gln938-Thr109	-1	1.02	1.47
Leu787-Arg170	-2	0.88	1.69
Leu902-Ala105	-1	0.83	1.75
Ala934-Val75	0	0.90	1.65
Asn942-Thr109	0	0.98	1.52
Ala790-Arg168	-1	1.00	2.25
Ala784-Pro136	-1	0.89	1.66
Gln938-Phe106	-3	0.56	1.31
Gly898-Asn132	0	0.48	2.28
Asn942-Pro108	-2	0.45	2.33
Leu902-Asn132	-3	0.52	1.43
Phe788-Arg168	-3	0.39	1.83
Cys906-Arg74	-3	0.40	1.79
Leu910-Gly73	-4	0.42	1.74
Phe788-Asn132	-3	0.26	2.22
Leu910-Arg74	-2	0.32	2.51
Total Score		72.24

Symbol	Atom match between
	C-alpha atoms within 3 A
	C-beta atoms within 3 A
	backbone atoms within 3 A
	side chain atoms within 2 A

The score for each residue pair is simply its BLOSUM score (if positive) + the sum of atom pair scores. The latter are between 0 and 1, with 0 for 3A distance or above and 1 for exact coordinate matches, linearly interpolated.