 Movie generated with PyMOL |
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A: c.1.8.1 (red/blue) 
B: a.52.1.2 (yellow) 
C: g.3.2.1 (green) 
Geometric Parameters
| RMSD A1-A2 | 0.35 |
| Shared interface atoms | 336 (90.1%) |
| Angle between green and yellow interface: | 6.87 |
| Angle between green and yellow domain: | 9.52 |
| Distance between center of mass of green and yellow interface (in Angstrom): | 2.88 |
| Distance between center of mass of green and yellow domain (in Angstrom) | 11.04 |
Sequence Alignment of domain c.1.8.1
kdanfasgrnsivhlfewkwndiadecerflqpqgfggvqisppneylvaDgrpWWerYQpvsyiintrsgdesaftdmt kdanfasgrnsivhlfewkwndiadecerflqpqgfggvqisppneylvadgrpWWerYqpvsyiintrsgdesaftdmt _ ## #_ rrcndagvriyvdavinhmtGMngvgtsgssadHDgmnypavpygsgdfhspcEVNNYQdadnvrncELVGLrdlnqgsd rrcndagvriyvdavinhmtGMngvgtsgssadhdgmnypavpygsgdfhspcEVNNYqdadnvrncELVGLrdlnqgsd ## __ #####_ ##### yvrgvlidymnhmidlgvagfRvDAakHmspgdlsvifsglknlntdygfadgarpfiyqEvIdlGGEaiskneytgfgc yvrgvlidymnhmidlgvagfrvDaaKHmspgdlsvifsglknlntdygfadgarpfiyqEVIdLggEaiskneytgfgc _ #_ _# #_# ___# vlefqfgvslgnafqggnqlknlanwgpewgllegldavvfvdnHDnqRTggsqiltyknpkpykmaiafmlahpygttr vleFqfgVslgnafqggnqlknlanwgpewgllegldavvfvdnhDNqRTGGsQIltyknpkpykmaiafmlahpygttr _ _ _#_ ##__ __ imssfdftdNDqgppqdgsgnlispginddntcsngyvcehrwrqvygmvgfrnave imssfdftdNDqgppqdgsgnlispginddntcsngyvcehrwrqvygmvgfrnave ## | |
Aligned interface residues . : # | 25 (71%) |
Aligned, similar interface residues (with positive BLOSUM value) : # | 25 (71%) |
| Raw BLOSUM-Score for the latter residues | 147 |
| Meaning | |
|---|---|
Capital letters |
Residue interacts with domain A |
# |
Identical interacting residues |
: |
Residues are similar and interact |
. |
Residues are not similar and interact |
_ |
Only one residue interacts |
Sequences of domain a.52.1.2 and g.3.2.1
SVGTSCIpgMAiphnpldscrwyvstrtcgvgprlatqemkarccrqleaiPAYcRcEavRilmDGVVTSSGqhegrllq dlpgcprqvqrafapklvtevecnlaTIHGgpfcLSL CIPKWNRCGpkMDgVpccepytcTSDYYGNcS |
Similarities between domain a.52.1.2 and g.3.2.1
| Residue Pair | Atom Matches | BLOSUM | Score | Avg.-Distance |
|---|---|---|---|---|
| Cys506-Cys508 | 
|
9 | 11.76 | 1.62 |
| Tyr554-Tyr528 |
|
7 | 9.44 | 1.54 |
| Tyr554-Tyr527 |
|
7 | 9.31 | 1.61 |
| Ile507-Ile502 |
|
4 | 4.77 | 2.23 |
| Arg556-Asp526 |
|
-2 | 3.94 | 1.52 |
| Ser505-Asn530 |
|
1 | 2.95 | 1.54 |
| Val567-Cys501 |
|
-1 | 2.83 | 1.79 |
| Val502-Tyr528 |
|
-1 | 2.28 | 0.72 |
| Leu615-Met512 | |
2 | 2.25 | 2.24 |
| Glu558-Val515 |
|
-2 | 2.15 | 1.71 |
| Met510-Ser532 |
|
-1 | 2.00 | 1.50 |
| Pro552-Thr524 |
|
-1 | 1.80 | 1.65 |
| Ser505-Asn506 | |
1 | 1.45 | 1.66 |
| Ala553-Tyr527 |
|
-2 | 1.51 | 1.49 |
| Ile608-Met512 | |
1 | 1.48 | 1.56 |
| Thr504-Arg507 |
|
-1 | 1.43 | 1.93 |
| Gly503-Arg507 |
|
-2 | 1.29 | 1.71 |
| Ala511-Asn530 |
|
-2 | 1.16 | 1.26 |
| Arg561-Val515 |
|
-3 | 1.12 | 1.88 |
| Pro552-Asp526 |
|
-1 | 1.19 | 1.21 |
| Ile507-Pro503 |
|
-3 | 0.92 | 1.62 |
| Thr607-Tyr527 |
|
-2 | 0.93 | 1.61 |
| Ile507-Asn506 |
|
-3 | 0.74 | 1.89 |
| Ala511-Thr524 |
|
0 | 0.69 | 1.97 |
| Pro552-Ser525 |
|
-1 | 0.66 | 2.00 |
| Ser501-Tyr528 | |
-2 | 0.42 | 1.74 |
| Val568-Cys501 |
|
-1 | 0.50 | 2.25 |
| Val502-Arg507 | |
-3 | 0.43 | 1.71 |
| Ser505-Arg507 | |
-1 | 0.31 | 2.08 |
| Glu558-Gly509 | |
-2 | 0.35 | 1.95 |
| Val502-Gly529 | |
-3 | 0.36 | 1.93 |
| Met510-Trp505 | |
-1 | 0.35 | 1.96 |
| Cys506-Ile502 | |
-1 | 0.37 | 1.88 |
| Arg561-Asp513 | |
-2 | 0.44 | 1.68 |
| Ala553-Asp526 | |
-2 | 0.20 | 2.39 |
| Cys506-Arg507 | |
-3 | 0.07 | 2.78 |
| Ile608-Tyr527 | |
-1 | 0.15 | 2.54 |
| Total Score | 73.99 | |||
| | ||||
| Symbol | Atom match between | |||
| C-alpha atoms within 3 A | |||
| C-beta atoms within 3 A | |||
| backbone atoms within 3 A | |||
| side chain atoms within 2 A | |||
|
The score for each residue pair is simply its BLOSUM score (if positive) + the sum of atom pair scores. The latter are between 0 and 1, with 0 for 3A distance or above and 1 for exact coordinate matches, linearly interpolated. | ||||
