Movie generated with PyMOL

A: b.47.1.2 (red/blue)

View b.47.1.2 in Scoppi
PDB: 1cgi (Search literature with GoPubMed)
FA: Eukaryotic proteases
SF: Trypsin-like serine proteases
SP: Cow (Bos taurus)/Cow (Bos taurus)

B: g.15.1.1 (yellow)

View g.15.1.1 in Scoppi
PDB: 1cgi (Search literature with GoPubMed)
FA: Animal Kazal-type inhibitors
SF: Ovomucoid/PCI-1 like inhibitors
SP: Human (Homo sapiens)

C: g.4.1.1 (green)

View g.4.1.1 in Scoppi
PDB: 1gl1_1
FA: PMP inhibitors
SF: PMP inhibitors
SP: Migratory locust (Locusta migratoria)
com Center of mass, domain b.47.1.2
com Center of mass, domain g.15.1.1
com Center of mass of interface atoms, domain g.15.1.1
com Center of mass, domain g.4.1.1
com Center of mass of interface atoms, domain g.4.1.1

Geometric Parameters

RMSD A1-A2 0.53
Shared interface atoms 296 (96.4%)
Angle between green and yellow interface: 3.94
Angle between green and yellow domain: 20.51
Distance between center of mass of green and yellow interface (in Angstrom): 1.40
Distance between center of mass of green and yellow domain (in Angstrom) 8.55

Sequence Alignment of domain b.47.1.2



cgvpaiqpvlsglsrivngeeavpgswpwqvslqdktgFHFCggslinenwvvtaaHCGVttsdvvvagefdqgssseki
cgvpaiqpvlsg---ivngeeavpgswpwqvslqDktgFHFCggslinenwvvtaaHCGvttsdvvvagefdqgssseki
                                  _   ####              ###_                     

qklkiakvfknskynSLTInnditllklstaasfsqtvsavclpsasddfaagttcvttgwgLtrYtnANTpdrlqqasl
qklkiakvfknskynSLTInnditllklstaasfsqtvsavclpsasddfaagttcvttgwgltr---yntpdrlqqasl
               ####                                           _     ___          

pllsntnckkyWgtKikdamicagasgvSSCMGDSggplvckkngawtlvgiVSWGSSTCststpGvyarvtalvnwvqq
pllsntnckkyWgtKikdamicagasgvsSCMGDSggplvckkngawtlvgiVSWGSSTCststpgvyarvtalvnwvqq
           #  #             _######                 ########     _               

tlaan
tlaan
Aligned interface residues 
. : #
 27 (77%)
Aligned, similar interface residues (with positive BLOSUM value) 
: #
 27 (77%)
Raw BLOSUM-Score for the latter residues 166
Meaning
    
Capital letters
 Residue interacts with domain A 
#
 Identical interacting residues 
:
 Residues are similar and interact 
.
 Residues are not similar and interact 
_
 Only one residue interacts
   

Sequences of domain g.15.1.1 and g.4.1.1



dslgreakcYNELNGCTYEYRPvcgtdgdTyPNecVlcFEnrKrqtsiliqksgPc 


IscepgkTfkdKcNTcRcgadgkSAACTLKACPn

Similarities between domain g.15.1.1 and g.4.1.1

Residue PairAtom MatchesBLOSUMScoreAvg.-Distance
Cys16-Cys28 ca cb bb bb bb sc sc sc 9 15.78 0.46
Thr17-Thr29 ca cb bb bb bb sc sc sc sc 5 12.42 0.53
Tyr18-Leu30 ca cb bb bb bb sc sc sc sc sc sc sc -1 9.18 0.71
Pro55-Pro34 bb sc sc 7 8.31 1.69
Asn33-Asn15 sc sc sc sc 6 8.18 1.36
Glu19-Lys31 ca cb bb bb bb sc sc sc 1 7.60 0.53
Pro22-Pro34 bb 7 7.08 2.76
Tyr20-Ala32 ca cb bb bb bb sc sc sc -2 5.90 0.79
Gly15-Ala27 ca bb bb bb sc 0 4.19 0.49
Lys43-Ile2 ca cb bb bb bb sc sc sc sc sc -3 3.55 1.93
Tyr10-Thr16 sc sc sc sc sc sc -2 3.23 1.38
Leu13-Arg18 cb bb bb sc sc sc sc -2 3.18 1.64
Pro22-Cys33 ca bb bb sc sc sc -3 2.68 1.66
Arg21-Lys31 sc 2 2.55 1.35
Arg21-Cys33 ca cb bb sc -3 1.62 1.79
Phe39-Ala26 sc sc sc -2 1.58 1.42
Asn11-Thr9 ca cb bb sc 0 1.06 2.20
Asn14-Ala27 bb bb -2 0.87 1.70
Glu19-Asn15 sc sc 0 0.93 1.61
Arg21-Ala32 bb -1 0.66 1.02
Phe39-Ile2 sc 0 0.44 1.69
Tyr10-Arg18 bb -2 0.38 1.87
Pro32-Lys13 sc -1 0.46 1.62
Asn33-Lys13 bb bb 0 0.31 2.54
Pro32-Cys33 bb -3 0.22 2.35
Asn14-Arg18 bb 0 0.11 2.67
Total Score 102.45
SymbolAtom match between
ca C-alpha atoms within 3 A
cb C-beta atoms within 3 A
bb backbone atoms within 3 A
sc side chain atoms within 2 A
The score for each residue pair is simply its BLOSUM score (if positive) + the sum of atom pair scores.
The latter are between 0 and 1, with 0 for 3A distance or above
and 1 for exact coordinate matches, linearly interpolated.