Movie generated with PyMOL

A: b.47.1.2 (red/blue)

View b.47.1.2 in Scoppi
PDB: 1acb (Search literature with GoPubMed)
FA: Eukaryotic proteases
SF: Trypsin-like serine proteases
SP: Cow (Bos taurus)/Pig (Sus scrofa)

B: d.40.1.1 (yellow)

View d.40.1.1 in Scoppi
PDB: 1acb (Search literature with GoPubMed)
FA: CI-2 family of serine protease inhibitors
SF: CI-2 family of serine protease inhibitors
SP: Leech (Hirudo medicinalis)

C: g.15.1.1 (green)

View g.15.1.1 in Scoppi
PDB: 1ldt (Search literature with GoPubMed)
FA: Animal Kazal-type inhibitors
SF: Ovomucoid/PCI-1 like inhibitors
SP: Medicinal leech (Hirudo medicinalis)
com Center of mass, domain b.47.1.2
com Center of mass, domain d.40.1.1
com Center of mass of interface atoms, domain d.40.1.1
com Center of mass, domain g.15.1.1
com Center of mass of interface atoms, domain g.15.1.1

Geometric Parameters

RMSD A1-A2 0.91
Shared interface atoms 200 (89.7%)
Angle between green and yellow interface: 2.50
Angle between green and yellow domain: 10.69
Distance between center of mass of green and yellow interface (in Angstrom): 1.60
Distance between center of mass of green and yellow domain (in Angstrom) 5.79

Sequence Alignment of domain b.47.1.2



cgvpaiqpvlsglivngeeavpgswpwqvslqdktgFHFCggslinenwvvtaaHCGvttsdvvvagefdqgsssekiqk
-------------ivggytcaansipyqvsln--sgsHFCggslinsqwvvsaaHC-YKsriqvrlgehnidvlegneqf
                                    _###              ## __                      

lkiakvfknskynslt-InnditllklstaasfsqtvsavclpsasddfaagttcvttgwgLtr--YanTpdrlqqaslp
inaakiithpnfngntL-dndimliklsspatlnsrvatvslp--rscaaagteclisgwgntksSgssYpsllqclkap
                                                             _    _  .           

llsntnckkyWgtKikdamicag--asgvsSCMGDSggplvckkngawtlvgiVSWGSStCststpgvyarvtalvnwvq
vlsdssckssypgQitgnmicvgfleggkDSCQGDSggpvvc----ngqlqgiVSWGYGCaQknkpGVYtkvcnyvnwiq
          _  :               _##.###                 ####..___    ___            

qtlaan
qtiaan
Aligned interface residues 
. : #
 19 (65%)
Aligned, similar interface residues (with positive BLOSUM value) 
: #
 15 (51%)
Raw BLOSUM-Score for the latter residues 95
Meaning
    
Capital letters
 Residue interacts with domain A 
#
 Identical interacting residues 
:
 Residues are similar and interact 
.
 Residues are not similar and interact 
_
 Only one residue interacts
   

Sequences of domain d.40.1.1 and g.15.1.1



ksfpevvgktvdqareyftlhypqydvyflpeGSPVTLDLRYnRvRvFynpgtnvvnhVpHvg 


KkVCACPKILKpvcgsdgrtyANscIarcngvsiksegscptgiln

Similarities between domain d.40.1.1 and g.15.1.1

Residue PairAtom MatchesBLOSUMScoreAvg.-Distance
Leu47-Leu10I ca cb bb bb bb sc sc sc sc sc 4 12.40 0.48
Leu45-Lys8I ca cb bb bb bb sc sc sc sc sc -2 8.25 0.52
Arg48-Lys11I ca cb bb bb bb sc sc sc sc sc 2 8.27 1.12
Asp46-Ile9I ca cb bb bb bb sc sc sc sc sc -3 7.76 0.67
Thr44-Pro7I ca cb bb bb bb sc sc sc sc -1 7.31 0.56
Val43-Cys6I ca cb bb bb bb sc sc sc sc -1 6.61 0.80
Pro42-Ala5I ca cb bb bb bb sc sc sc sc -1 5.85 1.05
Arg53-Ile26I ca cb bb bb bb sc -3 2.02 1.99
Arg51-Lys11I bb 2 2.08 2.77
Arg53-Asn23I sc sc sc sc 0 1.74 1.70
Arg51-Asn23I sc sc sc 0 1.76 1.24
Ser41-Ala5I bb 1 1.74 0.78
Ser41-Cys4I ca cb bb sc -1 1.68 1.74
Arg48-Ile9I sc sc sc -3 1.23 1.77
Gly40-Val3I bb -3 0.42 1.73
Tyr49-Lys11I bb -2 0.23 2.31
His68-Ala22I bb -2 0.05 2.86
Total Score 69.41
SymbolAtom match between
ca C-alpha atoms within 3 A
cb C-beta atoms within 3 A
bb backbone atoms within 3 A
sc side chain atoms within 2 A
The score for each residue pair is simply its BLOSUM score (if positive) + the sum of atom pair scores.
The latter are between 0 and 1, with 0 for 3A distance or above
and 1 for exact coordinate matches, linearly interpolated.